Identification of a cooperative effect between amino acids 169 and 174 in the rotavirus NSP4 double-layered particle-binding domain.

doi:10.1099/jgv.0.002029

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Article

Identification of a cooperative effect between amino acids 169 and 174 in the rotavirus NSP4 double-layered particle-binding domain.

The Journal of general virology - 1 Sept 2024

Herbert Jayme, van Dijk Alberdina A

Abstract excerpt

Segmented RNA viruses are capable of exchanging genome segments via reassortment as a means of immune evasion and to maintain viral fitness. Reassortments of single-genome segments are common among group A rotaviruses. Multiple instances of co-reassortment of two genome segments, GS6(VP6) and GS10(NSP4), have been documented in surveillance. Specifically, a division between NSP4 genotypes has been observed in the...

Topics

Viral Nonstructural Proteins
Rotavirus
Toxins, Biological
Glycoproteins
RNA, Viral
Protein Binding
Molecular Dynamics Simulation
Reassortant Viruses
Genotype
Amino Acid Sequence
Animals
Amino Acids
Nucleic Acid Conformation

Source

Open in PubMed

Identifiers

PMID: 39320365
DOI: 10.1099/jgv.0.002029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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