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Autophagy markers LC3 and p62 in aging lumbar motor neurons

18 Jun 2024

Abstract excerpt

Autophagy is a ubiquitous process through which damaged cytoplasmic structures are recycled and degraded within cells. Aging can affect autophagy regulation in different steps leading to the accumulation of damaged organelles and proteins, which can contribute to cell dysfunction and death. Motor neuron (MN) loss and sarcopenia are prominent features of neuromuscular aging. Previous studies on phrenic MNs showed...

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PMID: 38885913
DOI: 10.1016/j.exger.2024.112483

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