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Article

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection

8 Nov 2022

Abstract excerpt

BACKGROUND: Bepirovirsen is an antisense oligonucleotide that targets all hepatitis B virus (HBV) messenger RNAs and acts to decrease levels of viral proteins. METHODS: We conducted a phase 2b, randomized, investigator-unblinded trial involving participants with chronic HBV infection who were receiving or not receiving nucleoside or nucleotide analogue (NA) therapy. Participants were randomly assigned (in a...

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PMID: 36346079
DOI: 10.1056/nejmoa2210027

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