Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Severe invasive infections linked to IRAK2 immune variants.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Nov 2024

Amali Aseervatham Anusha, Paramasivam Kathirvel, Ravikumar Sharada, Tan Zhaohong, Loong Shaun Seh Ern, Chong Kelvin Han Chung, Ang Alicia, Zhu Jin, Rao Suma Sathyanarayana, Chai Louis Yi Ann

Abstract excerpt

In subjects with peculiar susceptibility to severe infections by common pyogenic bacteria, mutations of interleukin-1 receptor-associated kinase proteins (IRAK)1 and IRAK4 had been identified. The IRAK kinases function as downstream signal transductors following the activation of pathogen recognition receptors. In two patients with sequential or repeated invasive infections: herpes simplex virus-triggered...

Topics

Join the communities discussing this publication.

Bacteremia
Candidiasis
Herpes Simplex
Interleukin-1 Receptor-Associated Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphohistiocytosis, Hemophagocytic

Pneumococcal Infections

Streptococcus pneumoniae

Source

Identifiers

PMID: 39299377
DOI: 10.1016/j.ijid.2024.107245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe invasive infections linked to IRAK2 immune variants.PMID 39299377Read ↗

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.Semantic proximity Read ↗

Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4.Semantic proximity Read ↗

IRAK2 deficiency causes a new immune dysregulation disorderSemantic proximity Read ↗

Association of Polymorphisms in IRAK1, IRAK4 and MyD88, and Severe Invasive Pneumococcal Disease.Semantic proximity Read ↗

IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae.Semantic proximity Read ↗

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Semantic proximity Read ↗

Pyogenic bacterial infections in humans with IRAK-4 deficiency.Semantic proximity Read ↗

Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant.Semantic proximity Read ↗

IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB-Induced InflammationSemantic proximity Read ↗

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.Semantic proximity Read ↗

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.Semantic proximity Read ↗

IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB–Induced InflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.