Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

doi:10.1084/jem.20070628

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Article

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

The Journal of experimental medicine - 1 Oct 2007

Ku Cheng-Lung, von Bernuth Horst, Picard Capucine, Zhang Shen-Ying, Chang Huey-Hsuan, Yang Kun, Chrabieh Maya, Issekutz Andrew C, Cunningham Coleen K, Gallin John, Holland Steven M, Roifman Chaim, Ehl Stephan, Smart Joanne, Tang Mimi, Barrat Franck J, Levy Ofer, McDonald Douglas, Day-Good Noorbibi K, Miller Richard, Takada Hidetoshi, Hara Toshiro, Al-Hajjar Sami, Al-Ghonaium Abdulaziz, Speert David, Sanlaville Damien, Li Xiaoxia, Geissmann Frédéric, Vivier Eric, Maródi László, Garty Ben-Zion, Chapel Helen, Rodriguez-Gallego Carlos, Bossuyt Xavier, Abel Laurent, Puel Anne, Casanova Jean-Laurent

Abstract excerpt

Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3- and TLR4-interferon (IFN)-alpha/beta pathways. The clinical and immunological phenotype remains...

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PMID: 17893200
DOI: 10.1084/jem.20070628
PMCID: PMC2118442

Genes

TLR3
TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17893200-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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