Article
Susceptibility Screening of HIV-1 Viruses to Broadly Neutralizing Antibodies, Teropavimab and Zinlirvimab, in People With HIV-1 Suppressed by Antiretroviral Therapy.
Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2025
Selzer Lisa, VanderVeen Laurie A, Parvangada Aiyappa, Martin Ross, Collins Sean E, Mehrotra Megha, Callebaut Christian
Abstract excerpt
BACKGROUND: HIV envelope (env) diversity may result in resistance to broadly neutralizing antibodies (bNAbs). Assessment of genotypic or phenotypic susceptibility to antiretroviral treatment is often performed in people with HIV-1 (PWH) and used for clinical trial screening for HIV-1 bNAb susceptibility. Optimal bNAb susceptibility screening methods are not yet clear. METHODS: Phenotypic and genotypic analyses...
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