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Article

Evaluation of Broadly Neutralizing Antibody Sensitivity by Genotyping and Phenotyping for Qualifying Participants to HIV Clinical Trials.

Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2021

Moldt Brian, Parvangada Aiyappa, Martin Ross, Pace Craig, Balakrishnan Mini, Thomsen Nathan D, E Collins Sean, Kuster Herbert, Braun Dominique L, Günthard Huldrych F, Geleziunas Romas, Callebaut Christian

Abstract excerpt

BACKGROUND: HIV envelope (env) diversity represents a significant challenge for the use of broadly neutralizing antibodies (bNAbs) in HIV treatment and cure studies. Screening for viral sensitivity to bNAbs to select eligible trial participants will be important to improve clinical efficacy; however, no universal approach has been established. METHODS: Pre-antiretroviral therapy plasma virus from participants in...

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Share to Antibodies, Monoclonal, Humanized
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antiretroviral Therapy, Highly Active

Share to Broadly Neutralizing Antibodies

Share to Drug Resistance, Viral

Share to HIV Antibodies

Share to HIV Infections

Source

Identifiers

PMID: 34397744
DOI: 10.1097/QAI.0000000000002722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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