Article
Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia.
British journal of haematology - 1 Dec 2010
Pérez Benoîte, Kosmider Olivier, Cassinat Bruno, Renneville Aline, Lachenaud Julie, Kaltenbach Sophie, Bertrand Yves, Baruchel André, Chomienne Christine, Fontenay Michaela, Preudhomme Claude, Cavé Hélène
Abstract excerpt
JMML and CMML are rare myelodysplastic/myeloproliferative neoplasms occurring at both ends of life. To investigate relationships between JMML and CMML, genes recently involved in CMML were studied in 68 JMML patients. Mutations in TET2, RUNX1 and JAK2(V617F) are involved in myelodysplastic and/or myeloproliferative syndromes, and more specifically in CMML but were not found in JMML. Pangenomic analysis by...
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