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Article

Identification of antibody-resistant SARS-CoV-2 mutants via N4-Hydroxycytidine mutagenesis.

Antiviral research - 1 Nov 2024

Kumar Priya, Zhang Xiaoxiao, Shaha Rahul, Kschischo Maik, Dobbelstein Matthias

Abstract excerpt

Monoclonal antibodies targeting the Spike protein of SARS-CoV-2 are effective against COVID-19 and might mitigate future pandemics. However, their efficacy is challenged by the emergence of antibody-resistant virus variants. We developed a method to efficiently identify such resistant mutants based on selection from mutagenized virus pools. By inducing mutations with the active compound of Molnupiravir,...

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Antibodies, Monoclonal, Humanized
Antibodies, Neutralizing
Antibodies, Viral
COVID-19 Drug Treatment
Cytidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 39293594
DOI: 10.1016/j.antiviral.2024.106006

Genes

ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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