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Article

The expression of YAP1 and other transcription factors contributes to lineage plasticity in combined small cell lung carcinoma.

The journal of pathology. Clinical research - 1 Sept 2024

Jimbo Naoe, Ohbayashi Chiho, Fujii Tomomi, Takeda Maiko, Mitsui Suguru, Tanaka Yugo, Itoh Tomoo, Maniwa Yoshimasa

Abstract excerpt

Lineage plasticity in small cell lung carcinoma (SCLC) causes therapeutic difficulties. This study aimed to investigate the pathological findings of plasticity in SCLC, focusing on combined SCLC, and elucidate the involvement of YAP1 and other transcription factors. We analysed 100 surgically resected SCLCs through detailed morphological observations and immunohistochemistry for YAP1 and other transcription...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Basic Helix-Loop-Helix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Small Cell Lung Carcinoma

Share to Tumor Suppressor Protein p53

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Source

Open in PubMed Open full text

Identifiers

PMID: 39283755
DOI: 10.1002/2056-4538.70001
PMCID: PMC11404481

Genes

YAP1
NEUROD1
POU2F3
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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