Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation.

doi:10.1038/s44161-024-00532-x

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Article

Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation.

Nature cardiovascular research - 1 Sept 2024

Vyas Vishal, Sandhar Balraj, Keane Jack M, Wood Elizabeth G, Blythe Hazel, Jones Aled, Shahaj Eriomina, Fanti Silvia, Williams Jack, Metic Nasrine, Efremova Mirjana, Ng Han Leng, Nageswaran Gayathri, Byrne Suzanne, Feldhahn Niklas, Marelli-Berg Federica, Chain Benny, Tinker Andrew, Finlay Malcolm C, Longhi M Paula

Abstract excerpt

Atrial fibrillation (AF) is the most common sustained arrhythmia and carries an increased risk of stroke and heart failure. Here we investigated how the immune infiltrate of human epicardial adipose tissue (EAT), which directly overlies the myocardium, contributes to AF. Flow cytometry analysis revealed an enrichment of tissue-resident memory T (TRM) cells in patients with AF. Cellular indexing of transcriptomes...

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Identifiers

PMID: 39271815
DOI: 10.1038/s44161-024-00532-x
PMCID: PMC11399095

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