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HPV-YAP1 oncogenic alliance drives malignant transformation of fallopian tube epithelial cells

13 Sept 2024

Abstract excerpt

High grade serous ovarian carcinoma (HGSOC) is the most common and aggressive ovarian malignancy. Accumulating evidence indicates that HGSOC may originate from human fallopian tube epithelial cells (FTECs), although the exact pathogen(s) and/or molecular mechanism underlying the malignant transformation of FTECs is unclear. Here we show that human papillomavirus (HPV), which could reach FTECs via retrograde...

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PMID: 39271776
DOI: 10.1038/s44319-024-00233-3

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