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Clinical and cost-effectiveness of clopidogrel resistance genotype testing after ischaemic stroke or transient ischaemic attack: a systematic review and economic model.

Health technology assessment (Winchester, England) - 1 Sept 2024

Carroll Joe, Lopez Manzano Catalina, Tomlinson Eve, Sadek Ayman, Cooper Chris, Jones Hayley E, Rowsell Lorraine, Knight John, Mumford Andrew, Palmer Rachel, Hollingworth William, Welton Nicky J, Whiting Penny

Abstract excerpt

Background: Stroke or transient ischaemic attack patients are at increased risk of secondary vascular events. Antiplatelet medications, most commonly clopidogrel, are prescribed to reduce this risk. Factors including CYP2C19 genetic variants can hinder clopidogrel metabolism. Laboratory-based or point-of-care tests can detect these variants, enabling targeted treatment. Objective: To assess the effectiveness of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Ischemic Attack, Transient

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Identifiers

PMID: 39269241
DOI: 10.3310/PWCB4016
PMCID: PMC11417645

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Clinical and cost-effectiveness of clopidogrel resistance genotype testing after ischaemic stroke or transient ischaemic attack: a systematic review and economic model.PMID 39269241Read ↗

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