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Article

Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study.

BMJ open - 13 Dec 2021

Pilling Luke C, Türkmen Deniz, Fullalove Hannah, Atkins Janice L, Delgado Joao, Kuo Chia-Ling, Kuchel George A, Ferrucci Luigi, Bowden Jack, Masoli Jane A H, Melzer David

Abstract excerpt

OBJECTIVE: To determine whether CYP2C19 loss-of-function (LoF) alleles increase risk of ischaemic stroke and myocardial infarction (MI) in UK primary care patients prescribed clopidogrel. DESIGN: Retrospective cohort analysis. SETTING: Primary care practices in the UK from January 1999 to September 2017. PARTICIPANTS: 7483 European-ancestry adults from the UK Biobank study with genetic and linked primary care...

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Identifiers

PMID: 34903548
DOI: 10.1136/bmjopen-2021-053905
PMCID: PMC8671970

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