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Article

Genotype-guided ticagrelor/prasugrel versus clopidogrel therapy in stroke patients with CYP2C19 loss of function alleles: a systematic review and meta-analysis.

Pharmacogenomics - 1 Jan 2025

Biswas Mohitosh, Murad Murshadul Alam, Ershadian Maliheh, Sweety Shahnaz Parvin, Hasan Sakib Al, Sukasem Chonlaphat

Abstract excerpt

INTRODUCTION: Transient ischemic attack (TIA) or ischemic stroke (IS) patients may have recurrent stroke incidents, especially when carrying CYP2C19 Loss-of-Function (LoF) alleles and taking clopidogrel. Recent studies suggest using alternative antiplatelets, e.g., prasugrel, ticagrelor, in these patients. However, the aggregated risk of recurrent stroke or composite vascular events in CYP2C19 genotype-guided...

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Alleles
Clopidogrel
Cytochrome P-450 CYP2C19
Ischemic Attack, Transient
Platelet Aggregation Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prasugrel Hydrochloride

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Open in PubMed Open full text

Identifiers

PMID: 41450128
DOI: 10.1080/14622416.2025.2603565
PMCID: PMC12773629

Genes

CYP2C19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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