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Article

Genetically predicted HLA-DR+ natural killer cells as potential mediators in the lipid-coronary artery disease/ calcification (CAD/CAC) causal pathway.

Frontiers in immunology - 1 Jan 2024

Qian Dingding, Zhang Haoyue, Liu Rong, Ye Honghua

Abstract excerpt

Background: Coronary artery disease (CAD) imposes a significant global health burden, necessitating a deeper comprehension of its genetic foundations to uncover innovative therapeutic targets. Employing a comprehensive Mendelian randomization (MR) approach, we aimed to explore the genetic associations between lipid profiles, immune cell phenotypes, and CAD risk. Methods: Utilizing data from recent large-scale...

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Identifiers

PMID: 39267738
DOI: 10.3389/fimmu.2024.1408347
PMCID: PMC11390371

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CAD

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