Article
Commonly used genomic arrays may lose information due to imperfect coverage of discovered variants for autism spectrum disorder.
Journal of neurodevelopmental disorders - 12 Sept 2024
Yao Michael, Daniels Jason, Grosvenor Luke, Morrill Valerie, Feinberg Jason I, Bakulski Kelly M, Piven Joseph, Hazlett Heather C, Shen Mark D, Newschaffer Craig, Lyall Kristen, Schmidt Rebecca J, Hertz-Picciotto Irva, Croen Lisa A, Fallin M Daniele, Ladd-Acosta Christine, Volk Heather, Benke Kelly
Abstract excerpt
BACKGROUND: Common genetic variation has been shown to account for a large proportion of ASD heritability. Polygenic scores generated for autism spectrum disorder (ASD-PGS) using the most recent discovery data, however, explain less variance than expected, despite reporting significant associations with ASD and other ASD-related traits. Here, we investigate the extent to which information loss on the target study...
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