Article
Deleterious coding variation associated with autism is shared across ancestries.
Nature medicine - 1 Apr 2026
Natividad Avila Marina, Jung Seulgi, Satterstrom F Kyle, Fu Jack M, Levy Tess, Sloofman Laura G, Klei Lambertus, Pichardo Thariana, Marquez Dalia, Stevens Christine R, Cusick Caroline M, Ames Jennifer L, Campos Gabriele S, Cerros Hilda, Chaskel Roberto, Costa Claudia I S, Cuccaro Michael L, Lopez Andrea Del Pilar, Fernandez Magdalena, Ferro Eugenio, Galeano Liliana, Girardi Ana Cristina D E S, Griswold Anthony J, Hernandez Luis C, Lourenço Naila, Ludena Yunin, Núñez-Ríos Diana, Oyama Rosa, Peña Katherine P, Pessah Isaac, Schmidt Rebecca, Sweeney Holly M, Tolentino Lizbeth, Wang Jaqueline Y T, Albores-Gallo Lilia, Croen Lisa A, Cruz-Fuentes Carlos S, Hertz-Picciotto Irva, Kolevzon Alexander, Lattig Maria Claudia, Mayo Liliana, Passos-Bueno Maria Rita, Pericak-Vance Margaret A, Siper Paige M, Tassone Flora, Trelles M Pilar, Talkowski Michael E, Daly Mark J, Mahjani Behrang, De Rubeis Silvia, Cook Edwin H, Roeder Kathryn, Betancur Catalina, Devlin Bernie, Buxbaum Joseph D
Abstract excerpt
The past decade has seen remarkable progress in identifying genes that, when impacted by deleterious coding variation, confer high likelihood for autism spectrum disorder (ASD), intellectual disability and other associated developmental disorders. However, most underlying gene discovery efforts have focused on individuals of European ancestry, limiting insights into genetic liability across diverse populations....
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