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Evolution toward extremely high imipenem resistance in Mycobacterium abscessus outbreak strains

10 Sept 2024

Abstract excerpt

ABSTRACT Treatment of Mycobacterium abscessus pulmonary disease requires multiple antibiotics including intravenous β-lactams (e.g., imipenem). M. abscessus produces a β-lactamase (Bla Mab ) that inactivates β-lactam drugs but less efficiently carbapenems. Due to intrinsic and acquired resistance in M. abscessus and poor clinical outcomes, it is critical to understand the development of antibiotic resistance both...

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PMID: 39254295
DOI: 10.1128/aac.00673-24

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