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Genomic Analysis of Global Mycobacterium abscessus Isolates Reveals Ongoing Evolution of Drug Resistance–Associated Genes

26 Nov 2024

Abstract excerpt

Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5617 clinical MAB isolates from 20 countries and searched for signals of ongoing evolution in 35 drug resistance-associated genes. Of these, we found 14 genes that were subject to positive selection, and we identified novel mutational...

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PMID: 39589145
DOI: 10.1093/infdis/jiae580

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