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Article

Optimizing macrolide resistance detection for Mycobacterium abscessus: a potential low-cost, time-saving alternative.

Microbiology spectrum - 7 Oct 2025

Hwang Liang-En, Cheng Aristine, Sun Hsin-Yun, Chien Jung-Yien, Hsueh Po-Ren, Sheng Wang-Huei

Abstract excerpt

Mycobacterium abscessus complex (MABC) is notoriously difficult to treat. Current guidelines suggest a 14-day-long incubation and/or sequencing of erm41 to detect inducible macrolide resistance. We assessed whether the evolution of minimum inhibitory concentrations (MICs) can reliably predict inducible macrolide resistance and clinical outcomes of extrapulmonary MABC infections. Between 2013 and 2015, M....

Read the complete abstract on PubMed

Topics

Mycobacterium abscessus
Humans
Macrolides
Anti-Bacterial Agents
Microbial Sensitivity Tests
Mycobacterium Infections, Nontuberculous

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Resistance, Bacterial

Male

Middle Aged

Female

Aged

Adult

Clarithromycin

Sensitivity and Specificity

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 40919918
DOI: 10.1128/spectrum.00942-25
PMCID: PMC12502635

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DST

Provenance

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