Article

Evolution towards extremely high β-lactam resistance in <i>Mycobacterium abscessus</i> outbreak strains

2024-05-10

Abstract excerpt

Treatment of Mycobacterium abscessus pulmonary disease requires multiple antibiotics including intravenous β-lactams (e.g., imipenem, meropenem). M. abscessus produces a β-lactamase (Bla Mab ) that inactivates β-lactam drugs but less efficiently carbapenems. Due to intrinsic and acquired resistance in M. abscessus and poor clinical outcomes, it is critical to understand the development of antibiotic resistance...

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Literature Corpus work: 226280ab-daf5-5937-bcc8-06aedad8e221
DOI: 10.1101/2024.05.08.593223

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