Article
Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Nature communications - 8 Jun 2021
Kalisch-Smith Jacinta I, Ved Nikita, Szumska Dorota, Munro Jacob, Troup Michael, Harris Shelley E, Rodriguez-Caro Helena, Jacquemot Aimée, Miller Jack J, Stuart Eleanor M, Wolna Magda, Hardman Emily, Prin Fabrice, Lana-Elola Eva, Aoidi Rifdat, Fisher Elizabeth M C, Tybulewicz Victor L J, Mohun Timothy J, Lakhal-Littleton Samira, De Val Sarah, Giannoulatou Eleni, Sparrow Duncan B
Abstract excerpt
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular...
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