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Article

Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 2024

Oppelaar Jetta J, Ferwerda Bart, Romman Mohamed A, Sahebdin Ghazalah N, Zwinderman Aeilko H, Galenkamp Henrike, Boekholdt S Matthijs, van den Born Bert-Jan H, Olde Engberink Rik H G, Vogt Liffert

Abstract excerpt

BACKGROUND: High heritability of salt sensitivity suggests an essential role for genetics in the relationship between sodium intake and blood pressure (BP). The role of glycosaminoglycan genes, which are crucial for salinity tolerance, remains to be elucidated. METHODS: Interactions between 54 126 variants in 130 glycosaminoglycan genes and daily sodium excretion on BP were explored in 20 420 EPIC-Norfolk...

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Source

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Identifiers

PMID: 39247955
DOI: 10.1161/HYPERTENSIONAHA.124.23421
PMCID: PMC11404764

Genes

NDST3
HS3ST5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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