Article
Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma.
Cancer cell - 14 Oct 2024
Curry Rachel N, Ma Qianqian, McDonald Malcolm F, Ko Yeunjung, Srivastava Snigdha, Chin Pey-Shyuan, He Peihao, Lozzi Brittney, Athukuri Prazwal, Jing Junzhan, Wang Su, Harmanci Arif O, Arenkiel Benjamin, Jiang Xiaolong, Deneen Benjamin, Rao Ganesh, Serin Harmanci Akdes
Abstract excerpt
Prior studies have described the complex interplay that exists between glioma cells and neurons; however, the electrophysiological properties endogenous to glioma cells remain obscure. To address this, we employed Patch-sequencing (Patch-seq) on human glioma specimens and found that one-third of patched cells in IDH mutant (IDHmut) tumors demonstrate properties of both neurons and glia. To define these hybrid...
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