Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

Abstract excerpt

Prior studies have described the complex interplay that exists between glioma cells and neurons, however, the electrophysiological properties endogenous to tumor cells remain obscure. To address this, we employed Patch-sequencing on human glioma specimens and found that one third of patched cells in IDH mutant (IDH mut ) tumors demonstrate properties of both neurons and glia by firing single, short action potent...

Topics

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• Action Potentials
• Brain Neoplasms
• Electrophysiological Phenomena
• GABAergic Neurons
• Glioma
• Isocitrate Dehydrogenase
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

0cca50d9-cb29-5a3b-8e9d-779ef11345e3

DOI

10.1101/2024.03.02.583026