Article
The evolutionary biology of dengue virus.
Novartis Foundation symposium - 1 Jan 2006
Holmes Edward C
Abstract excerpt
Studies of the evolution of dengue virus (DENV) have blossomed during the last 20 years, in part due to the increasing availability of viral gene sequence data. Herein I review key aspects of the evolutionary biology of DENV focusing on extent and structure of genetic diversity in DENV, the time and place of DENV origin, the major mechanisms of DENV evolution, and the evolution of DENV virulence. A central...
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