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Article

Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction.

PloS one - 1 Jan 2024

Chen Keming, Huang Bincheng, Feng Jiajing, Hu Zhengxing, Fan Shuzhe, Ren Shuai, Tian Haifu, Abdulkarem M M Al-Qaisi Mohammed, Wang Xuehao, Tuo Yunshang, Liang Xiaoxia, Xie Haibo, He Rui, Li Guangyong

Abstract excerpt

OBJECTIVE: This study aims to explore the impact of Nesfatin-1 on type 2 diabetic erectile dysfunction (T2DMED) and its underlying mechanism in regulating the phenotypic switching of corpus cavernosum smooth muscle cells (CCSMCs). METHODS: Twenty-four 4-week-old male C57 wild-type mice were randomly assigned to the control group, model group, and Nesfatin-1 treatment group. Monitoring included body weight, blood...

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Calcium-Binding Proteins
Diabetes Mellitus, Experimental
Erectile Dysfunction
Myocytes, Smooth Muscle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-akt

TOR Serine-Threonine Kinases

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Identifiers

PMID: 39226294
DOI: 10.1371/journal.pone.0304485
PMCID: PMC11371211

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