Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the human genomic landscape: patterns of common homozygosity regions in a large middle eastern cohort.

Human molecular genetics - 5 Nov 2024

Sagi-Dain Lena, Levy Michal, Matar Reut, Kahana Sarit, Agmon-Fishman Ifaat, Klein Cochava, Gurevitch Merav, Basel-Salmon Lina, Maya Idit

Abstract excerpt

Regions of Homozygosity (ROH) typically reflect normal demographic history of a human population, but may also relate to cryptic consanguinity, and, additionally, have been associated with specific medical conditions. The objective of this study was to investigate the location, size, and prevalence of common ROH segments in a Middle Eastern cohort. This retrospective study included 13 483 samples collected from...

Topics

Join the communities discussing this publication.

Cohort Studies
Consanguinity
Genome, Human
Genomics
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 39222050
DOI: 10.1093/hmg/ddae123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the human genomic landscape: patterns of common homozygosity regions in a large middle eastern cohort.PMID 39222050Read ↗

Long contiguous stretches of homozygosity detected by chromosomal microarrays (CMA) in patients with neurodevelopmental disorders in the South of BrazilSemantic proximity Read ↗

Regions of homozygosity and their impact on complex diseases and traits.Semantic proximity Read ↗

Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in BloodSemantic proximity Read ↗

Patterns and drivers of 43,617 mosaic chromosomal alterations in bloodSemantic proximity Read ↗

Interpretation and reporting of large regions of homozygosity and suspected consanguinity/uniparental disomy, 2021 revision: A technical standard of the American College of Medical Genetics and Genomics (ACMG).Semantic proximity Read ↗

Regions of homozygosity identified by oligonucleotide SNP arrays: evaluating the incidence and clinical utility.Semantic proximity Read ↗

Chromosomal microarray in a highly consanguineous population: diagnostic yield, utility of regions of homozygosity, and novel mutations.Semantic proximity Read ↗

Genomics of rare diseases in the Greater Middle East.Semantic proximity Read ↗

Large regions of homozygosity in prenatal diagnosis.Semantic proximity Read ↗

Patterns and drivers of 43,617 mosaic chromosomal alterations in blood.Semantic proximity Read ↗

Population Analysis of Large Copy Number Variants and Hotspots of Human Genetic DiseaseSemantic proximity Read ↗

Long contiguous stretches of homozygosity in the human genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.