Article
N121T and N121S substitutions on the SARS-CoV-2 spike protein impact on serum neutralization.
Journal of medical virology - 1 Sept 2024
Lo Van Thi, Lim Hyun A, Jang Seong Sik, Kim Min Chan, Chamfort Alain Chrysler, Kim Ha Yeon, Mun Da Young, Kang Min Chang, Lee Han Byul, Kim Sunjoo, Lee Younghee, Park Sangkyu, Yoon Sun-Woo, Kim Hye Kwon
Abstract excerpt
The N121 site on the spike protein of SARS-CoV-2 is associated with heme and its metabolite, biliverdin, which can affect antibody binding. Both N121T and N121S substitutions have been observed in natural conditions and in a hamster model of dual infection with SARS-CoV-2 and Influenza A virus. Serum pseudotype neutralization assays against HIV-1 particles carrying wild-type, N121T, and N121S spikes with immune...
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