Article
Inactivation of Pseudovirus Expressing the D614G Spike Protein Mutation using Nitric Oxide-Plasma Activated Water.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2024
Patel Paritosh, Kaushik Neha, Acharya Tirtha Raj, Lenka Sudakshya S, Ghosh Soujanya, Wahab Rizwan, Verma Suresh K, Choi Eun Ha, Kaushik Nagendra Kumar
Abstract excerpt
Variants of concern (VOCs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) exhibit high infectivity due to mutations, particularly in the spike protein, that facilitate enhanced binding of virus to human angiotensin-converting enzyme 2 (hACE2). The D614G mutation, situated in S1-domain, promotes the open conformation of spike protein, augmenting its interaction with hACE2. Activated water...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.