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Mitophagy’s impacts on cancer and neurodegenerative diseases: implications for future therapies

1 Aug 2025

Abstract excerpt

Substantial evidence supports an inverse relationship between cancer and neurodegenerative diseases (NDDs), but few studies investigate the biological mechanisms underlying this phenomenon. While previous explanations-such as inflammation, reactive oxygen species (ROS), genetic mutations, and cell death-remain significant, they ultimately converge on mitophagy. This review identifies mitophagy as a pivotal factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40750884
DOI: 10.1186/s13045-025-01727-w

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