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Genome wide DNA methylation analysis identifies novel molecular subgroups and predicts survival in neuroblastoma

29 Sept 2022

Abstract excerpt

BACKGROUND: Neuroblastoma is the most common malignancy in infancy, accounting for 15% of childhood cancer deaths. Outcome for the high-risk disease remains poor. DNA-methylation patterns are significantly altered in all cancer types and can be utilised for disease stratification. METHODS: Genome-wide DNA methylation (n = 223), gene expression (n = 130), genetic/clinical data (n = 213), whole-exome sequencing (n...

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PMID: 36175618
DOI: 10.1038/s41416-022-01988-z

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