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Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

25 Mar 2024

Abstract excerpt

Allergic contact dermatitis (ACD), a prevalent inflammatory skin disease, is elicited upon repeated skin contact with protein-reactive chemicals through a complex and poorly characterized cellular network between immune cells and skin resident cells. Here, single-cell transcriptomic analysis of the murine hapten-elicited model of ACD reveals that upon elicitation of ACD, infiltrated CD4 + or CD8 + lymphocytes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39213029
DOI: 10.7554/elife.94698

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