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Article

Leptin and insulin synergize with PIK3CA mutation to enhance PD-L1 mediated immunosuppression in thyroid cancer.

Experimental cell research - 1 Oct 2024

Wu Kainan, Chen Yuerong, Guo Runsheng, Zeng Qingtan, Yu Yue

Abstract excerpt

The incidence of thyroid cancer keeps rising and obesity emerges as an important risk factor for thyroid cancer, but the underlying mechanism is far from clear. Here, we hypothesize that leptin and insulin, two hormones closely related to obesity, may contribute to the pathogenesis of thyroid cancer. By using a combination of assays like CRISPR KO, cancer cell-T cell co-culture, ApoLive-Glo™ multiplex assay and...

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Share to B7-H1 Antigen
Share to Cell Line, Tumor
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39209143
DOI: 10.1016/j.yexcr.2024.114229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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