Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder.

PLoS genetics - 1 Oct 2016

Wang Yiqin, Picard Martin, Gu Zhenglong

Abstract excerpt

Increasing clinical and biochemical evidence implicate mitochondrial dysfunction in the pathophysiology of Autism Spectrum Disorder (ASD), but little is known about the biological basis for this connection. A possible cause of ASD is the genetic variation in the mitochondrial DNA (mtDNA) sequence, which has yet to be thoroughly investigated in large genomic studies of ASD. Here we evaluated mtDNA variation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder
Share to DNA, Mitochondrial
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Mitochondria

Share to Pedigree

Share to Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 27792786
DOI: 10.1371/journal.pgen.1006391
PMCID: PMC5085253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder.PMID 27792786Read ↗

Association Between Mitochondrial DNA Haplogroup Variation and Autism Spectrum Disorders.Semantic proximity Read ↗

No Association Between Autism Spectrum Disorder and Mitochondrial DNA Variants: A Comprehensive Genetic Study in Trakya Population.Semantic proximity Read ↗

Mitochondrial DNA Variants in Autism Spectrum Disorder: A Systematic ReviewSemantic proximity Read ↗

Genomic architecture of autism from comprehensive whole-genome sequence annotation.Semantic proximity Read ↗

Postzygotic single-nucleotide mosaicisms contribute to the etiology of autism spectrum disorder and autistic traits and the origin of mutations.Semantic proximity Read ↗

Mitochondrial DNA Haplogroup K Is Protective Against Autism Spectrum Disorder Risk in Populations of European Ancestry.Semantic proximity Read ↗

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.Semantic proximity Read ↗

Next Generation Sequencing Mitochondrial DNA Analysis in Autism Spectrum Disorder.Semantic proximity Read ↗

Evaluating mitochondrial DNA variation in autism spectrum disorders.Semantic proximity Read ↗

Reassessing the role of mitochondrial DNA mutations in autism spectrum disorder.Semantic proximity Read ↗

Whole-genome sequencing of quartet families with autism spectrum disorder.Semantic proximity Read ↗

Exonic Mosaic Mutations Contribute Risk for Autism Spectrum Disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.