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Article

Predicting Drug Resistance Using Deep Mutational Scanning.

Molecules (Basel, Switzerland) - 11 May 2020

Pines Gur, Fankhauser Reilly G, Eckert Carrie A

Abstract excerpt

Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences. Recent genome editing technologies based on high-throughput DNA synthesis and sequencing may help to predict mutations resulting in resistance by testing large mutagenesis...

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PMID: 32403408
DOI: 10.3390/molecules25092265
PMCID: PMC7248951

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Source receipt: pubmed, retrieved 6 Sept 2026.

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