Article

Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children

2022-04-11

Abstract excerpt

<title>Abstract</title> <p>Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcome were previously correlated with Notch4 expression on regulatory T (Treg) cells, here we show that the Treg cells in MIS-C are destabilized in association with increased Notch1 expres...

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Literature Corpus work: ec40868e-bd57-56ed-a6c2-0fb55319c3d7
DOI: 10.21203/rs.3.rs-1054453/v1

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