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Article

Implementation of TPMT testing.

British journal of clinical pharmacology - 1 Apr 2014

Lennard Lynne

Abstract excerpt

The activity of the enzyme thiopurine methyltransferase (TPMT) is regulated by a common genetic polymorphism. One in 300 individuals lack enzyme activity and 11% are heterozygous for a variant low activity allele and have an intermediate activity. The thiopurine drugs azathioprine, mercaptopurine and thioguanine are substrates for TPMT; these drugs exhibit well documented myelosuppressive effects on...

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Share to Purine-Pyrimidine Metabolism, Inborn Errors
Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Hypersensitivity

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Source

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Identifiers

PMID: 23962279
DOI: 10.1111/bcp.12226
PMCID: PMC3971986

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Implementation of TPMT testing.PMID 23962279Read ↗

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