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Article

HLA class I NK-epitopes and KIR diversities in patients with multiple myeloma.

Immunogenetics - 1 Jun 2024

Beelen Nicky A, Molenbroeck Stefan J J, Groeneveld Lisette, Voorter Christien E, Bos Gerard M J, Wieten Lotte

Abstract excerpt

Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of malignant plasma cells in the bone marrow. Myeloma cells are susceptible to killing by natural killer (NK) cells, but NK cells fail to control disease progression, suggesting immunosuppression. The activation threshold of NK-effector function is regulated by interaction between KIRs and self-HLA class I, during a process called...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38478091
DOI: 10.1007/s00251-024-01336-w
PMCID: PMC11087314

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