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Article

Tretinoin synergistically enhances the antitumor effect of combined BRAF, MEK, and EGFR inhibition in BRAFV600E colorectal cancer.

Cancer science - 1 Nov 2024

Yoshida Yuya, Takahashi Masanobu, Taniguchi Sakura, Numakura Ryunosuke, Komine Keigo, Ishioka Chikashi

Abstract excerpt

Patients with BRAF-mutated colorectal cancer (BRAFV600E CRC) are currently treated with a combination of BRAF inhibitor and anti-EGFR antibody with or without MEK inhibitor. A fundamental problem in treating patients with BRAFV600E CRC is intrinsic and/or acquired resistance to this combination therapy. By screening 78 compounds, we identified tretinoin, a retinoid, as a compound that synergistically enhances the...

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PMID: 39175203
DOI: 10.1111/cas.16280
PMCID: PMC11531965

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