Article
A correctable decoding DNA sequencing with high accuracy and high throughput.
Analytical methods : advancing methods and applications - 12 Sept 2024
Cheng Chu, Cheng Qingzhou, Zhou Wei, Chen Yulong, Liu Wenbin, Zhang Zhiling, Ye Jingsi, Xiao Pengfeng
Abstract excerpt
Eliminating errors in next-generation sequencing has proven to be challenging. Here we present a novel strategy for DNA sequencing, called correctable two-color fluorogenic DNA decoding sequencing, which can significantly improve sequencing accuracy and throughput by employing a dual-nucleotide addition combined with fluorogenic sequencing-by-synthesis (SBS) chemistry. This sequencing method involves introducing...
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