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The structure of the Lujo virus spike complex

21 Aug 2024

Abstract excerpt

Lujo virus (LUJV) is a human pathogen that was the cause of a deadly hemorrhagic fever outbreak in Africa. LUJV is a divergent member of the Arenaviridae with some similarities to both the "Old World" and "New World" serogroups, but it uses a cell-entry receptor, neuropilin-2 (NRP2), that is distinct from the receptors of OW and NW viruses. Though the receptor binding domain of LUJV has been characterized...

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PMID: 39169025
DOI: 10.1038/s41467-024-51606-0

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