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Article

Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration

21 Aug 2024

Abstract excerpt

Purpose: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD. Cellular senescence contributes to the development of numerous age-associated diseases. In this study, we investigated the link between cholesterol burden and the cellular senescence of photoreceptors. Methods: Retinas from rod-specific ATP binding cassette subfamily A member 1 (Abca1) and G member 1 (Abcg1) (Abca1/g1-rod/-rod)...

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PMID: 39167399
DOI: 10.1167/iovs.65.10.29

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