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Cellular Senescence in Age‐Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

1 Jan 2017

Abstract excerpt

Age‐related macular degeneration (AMD) is the main reason of blindness in developed countries. Aging is the main AMD risk factor. Oxidative stress, inflammation and some genetic factors play a role in AMD pathogenesis. AMD is associated with the degradation of retinal pigment epithelium (RPE) cells, photoreceptors, and choriocapillaris. Lost RPE cells in the central retina can be replaced by their peripheral...

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PMID: 29225722
DOI: 10.1155/2017/5293258

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