Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TP53 mutations and survival in patients with histologically defined Glioblastoma, IDH-wildtype.

Pathology, research and practice - 1 Oct 2024

Di Nunno Vincenzo, Gatto Lidia, Tosoni Alicia, Aprile Marta, Galvani Linda, Zappi Arianna, Foschini Maria Pia, Asioli Sofia, Tallini Giovanni, De Biase Dario, Maloberti Thais, Bartolini Stefania, Giannini Caterina, Franceschi Enrico

Abstract excerpt

BACKGROUND: Mutations of the TP53 oncosuppressor gene are frequent events in patients with malignant tumors including IDH-wildtype GBM (GBM IDH wt). However, the effective impact of TP53 mutations on prognosis has been poorly evaluated. METHODS: We performed a retrospective study investigating the impact of TP53 mutations on patients with GBM IDH wt. Only patients with PS=0-1, treated with temozolomide concurrent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Prognosis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 39163733
DOI: 10.1016/j.prp.2024.155516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TP53 mutations and survival in patients with histologically defined Glioblastoma, IDH-wildtype.PMID 39163733Read ↗

Molecular characterization and survival analysis of a cohort of glioblastoma, IDH-wildtype.Semantic proximity Read ↗

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes.Semantic proximity Read ↗

TERT promoter mutation as an independent prognostic marker in Glioblastoma: a prospective comparative studySemantic proximity Read ↗

Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network.Semantic proximity Read ↗

Prognostic impact of CDKN2A/B deletion, TERT mutation, and EGFR amplification on histological and molecular IDH-wildtype glioblastomaSemantic proximity Read ↗

Gain of function of mutant TP53 in glioblastoma: prognosis and response to temozolomide.Semantic proximity Read ↗

Neuro-oncology: TERT promoter mutations could indicate poor prognosis in glioblastoma.Semantic proximity Read ↗

Telomerase reverse transcriptase promoter mutation- and O6-methylguanine DNA methyltransferase promoter methylation-mediated sensitivity to temozolomide in isocitrate dehydrogenase-wild-type glioblastoma: is there a link?Semantic proximity Read ↗

Long Term Survival in Patients Suffering from Glioblastoma Multiforme: A Single-Centre Observational Cohort StudySemantic proximity Read ↗

Blood-tissue analysis of TP53 polymorphisms and survival of patients with glioma.Semantic proximity Read ↗

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.Semantic proximity Read ↗

TERT Promoter Mutation in Adult Glioblastomas: It's Correlation with Other Relevant Molecular Markers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.