Telomerase reverse transcriptase promoter mutation- and O6-methylguanine DNA methyltransferase promoter methylation-mediated sensitivity to temozolomide in isocitrate dehydrogenase-wild-type glioblastoma: is there a link?

doi:10.1016/j.ejca.2021.01.014

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Telomerase reverse transcriptase promoter mutation- and O6-methylguanine DNA methyltransferase promoter methylation-mediated sensitivity to temozolomide in isocitrate dehydrogenase-wild-type glioblastoma: is there a link?

European journal of cancer (Oxford, England : 1990) - 1 Apr 2021

Gramatzki Dorothee, Felsberg Jörg, Hentschel Bettina, Wolter Marietta, Schackert Gabriele, Westphal Manfred, Regli Luca, Thon Niklas, Tatagiba Marcos, Wick Wolfgang, Schlegel Uwe, Krex Dietmar, Matschke Jakob, Roth Patrick, Suresh Marian P, Kamp Marcel A, Rushing Elisabeth J, Pietsch Torsten, von Deimling Andreas, Sabel Michael, Loeffler Markus, Weller Michael, Reifenberger Guido

Abstract excerpt

AIM OF THE STUDY: Benefit from temozolomide (TMZ) chemotherapy in the treatment of isocitrate dehydrogenase (IDH)-wild-type glioblastoma is essentially limited to patients with O6-methylguanine DNA methyltransferase (MGMT) promoter-methylated tumours. Recent studies suggested that telomerase reverse transcriptase (TERT) promoter hotspot mutations may have an impact on the prognostic role of the MGMT status in...

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PMID: 33631540
DOI: 10.1016/j.ejca.2021.01.014

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