Article
The RAD51 S181P mutation shortens lifespan of female mice.
Mutation research - 1 Jan 2000
Dodds Sherry G, Hubbard Gene, Choi Yong Jun, Myung Kyungjae, Elliot Gene, Garrett Lisa, Kim Tae Moon, Hasty Paul
Abstract excerpt
RAD51 is critical to the homologous recombination (HR) pathway that repairs DNA double strand breaks (DSBs) and protects replication forks (RFs). Previously, we showed that the S181P (SP) mutation in RAD51 causes defective RF maintenance but is proficient for DSB repair. Here we report that SP/SP female mice exhibit a shortened lifespan compared to +/+ females but not males. Histological analysis found that most...
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