Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality

1 Jan 2024

Abstract excerpt

Previous study has found that PRSS50 (TSP50) is highly expressed in spermatocytes, and our study aims to investigate its role in testicular development and spermatogenesis. We first found that PRSS50 knockdown hindered DNA synthesis of spermatocytes. Then we generated Prss50-/- (PRSS50 knockout) mice and found that it exhibited abnormal compression of spermatid nucleus and reduced male fertility. Furthermore,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39147718
DOI: 10.24272/j.issn.2095-8137.2023.388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm qualityPMID 39147718Read ↗

Testis‐specific serine kinase 3 is required for sperm morphogenesis and male fertilitySemantic proximity Read ↗

PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.Semantic proximity Read ↗

MAPKs signaling is obligatory for male reproductive function in a development-specific mannerSemantic proximity Read ↗

Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertilitySemantic proximity Read ↗

The testes‐specific bZip type transcription factor <i>Tisp40</i> plays a role in ER stress responses and chromatin packaging during spermiogenesisSemantic proximity Read ↗

Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviductSemantic proximity Read ↗

Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathwaySemantic proximity Read ↗

Mitogen activated protein kinases (MAPKs) as regulators of spermatogenesis and spermatozoa functionsSemantic proximity Read ↗

The expression level of septin12 is critical for spermiogenesis.Semantic proximity Read ↗

TSSK3, a novel target for male contraception, is required for spermiogenesisSemantic proximity Read ↗

Protein Phosphatase 4 (PPP4) Prevents Female Reprogramming in the Mouse Testis After Sex Determination and Protects Male FertilitySemantic proximity Read ↗

Identification of abnormal protein expressions associated with mouse spermatogenesis induced by cyclophosphamideSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.