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Article

Identification of abnormal protein expressions associated with mouse spermatogenesis induced by cyclophosphamide

12 Jan 2021

Abstract excerpt

Cyclophosphamide (CP) is a clinical anticancer drug that can cause male reproductive abnormalities, but the underlying mechanisms for this remain unknown. The present study aimed to explore the potential toxicity induced by CP in spermatogenesis events of germ cell proliferation, meiosis, and blood-testis barrier integrity at the molecular level. CP-treated mice showed significantly reduced serum testosterone...

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PMID: 33438283
DOI: 10.1111/jcmm.16263

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